The TRP1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TYRP1. This antibody recognizes Human, Mouse, and Rat antigen. The TRP1 Antibody has been validated for the following applications: EIA, Immunoassay, and ELISA.
Description
Function: Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
Post Translational Modifications: Glycosylated.
Subcellular Location: Melanosome membrane>Single-pass type I membrane protein. Melanosome. Note: Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Tissue Specificity: Pigment cells.
Subunit Structure: Monomer.
Similarity: Belongs to the tyrosinase family